We are a team of researchers from various disciplines (mathematics, physics, biology, computer science) embedded into a large cancer research center, Institut Curie, and working together on answering major questions of cancer biology. In our projects, we develop mathematical models of biological processes leading to changing cell or cell environment state from normal healthy to malignant and potentiating tumoral transformation. We develop computational methods to deal with new types of molecular omics data, provided by our collaborators, exploiting formalized biological knowledge in the form of interaction networks. We develop our own sources of pathway information relevant to cancer biology. Finally, we perform various types of integrative omics data analyses using appropriate machine learning and statistical methods. The group has multiple collaborations with molecular biologists, geneticists, medical doctors as well as computational biologists in France and other countries. The computational systems biology group at Institut Curie exists since 2008 as a part of INSERM U900 bioinformatics and computational biology of cancer unit.

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